pH-responsive vectors are typically designed using polymers that contain ionizable weak acids or weak bases to exploit the acidic microenvironment for controlled 

delivery systems activated by external remote triggers are also discussed. We conclude by discus-sing advantages and limitations of current strategies, as well as future opportunities and challenges in this area. KEYWORDS diabetes, drug delivery, insulin, stimuli-responsive 1 | INTRODUCTION

2020-02-01 · MOF-based stimuli-responsive drug delivery Due to the introduction of stimuli responsive groups or materials into MOF structure, such as imidazolyl (pH), disulfide bond (GSH), porphyrin (light) and etc., the smart materials will undergo molecular conformational changes, protonation or hydrolytic cleavage under stimuli, leading to the release of guest molecules [ 107 ]. Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. In this study, we reviewed state-of-the-art endogenous-based and exogenous-based stimuli-responsive drug delivery systems (DDS) for programmed site-specific release to overcome the drawbacks of conventional therapeutic modalities. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields.

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Stimuli-sensitive polymersomes have emerged as novel programmable delivery systems in which the release of the encapsulated contents can be readily modulated by the stimulus. The stimuli-responsive release may result in significantly enhanced therapeutic efficacy and minimized possible side effects. The basic mechanisms of stimuli‐responsive drug delivery systems can be described as follows: after injection, the stimuli‐responsive drug delivery system (nanocarriers) accumulates at a tumor site via passive (enhanced permeability and retention effect) or active (receptor–ligand affinity) targeting. The “stimuli-responsive molecularly imprinted polymers” reviewed in this paper are expected to contribute significantly to the exploration and development of new generations of intelligent and self-regulated drug delivery systems. Keywords: Molecularly imprinted polymers, stimuli-responsive systems, intelligent drug delivery Stimuli-Responsive Materials for Controlled Drug Delivery Stimuli-responsive materials, which exhibit changes in one or more properties in response to an external trigger, have gained interest due to their tunability and versatility. Targeted and stimuli-responsive biomaterials, are promising for various applications in drug delivery.

2019-06-14 · This chapter focuses on cyclodextrins and their derivatives as stimuli-responsive polymeric nanocarriers for drug delivery and biomedical applications. The responsive cyclodextrins are able to control drug release in response to either exogenous stimuli such as temperature, light intensity, and magnetic field or endogenous stimuli like pH, enzyme concentration, and oxidation-reduction potential.

Epub 2013 Apr 20. Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor. 2019-06-14 · This chapter focuses on cyclodextrins and their derivatives as stimuli-responsive polymeric nanocarriers for drug delivery and biomedical applications. The responsive cyclodextrins are able to control drug release in response to either exogenous stimuli such as temperature, light intensity, and magnetic field or endogenous stimuli like pH, enzyme concentration, and oxidation-reduction potential.

Stimuli-responsive liposomes for drug delivery The ultimate goal of drug delivery is to increase the bioavailability and reduce the toxic side effects of the active pharmaceutical ingredient (API) by releasing them at a specific site of action.

Thus, the emphasis was given to the drug release mechanism and applications of endogenous and exogenous based stimuli-responsive DDS in the clinical settings. In this study, we reviewed state-of-the-art endogenous-based and exogenous-based stimuli-responsive drug delivery systems (DDS) for programmed site-specific release to overcome the drawbacks of conventional therapeutic modalities. Stimuli-responsive materials, which exhibit changes in one or more properties in response to an external trigger, have gained interest due to their tunability and versatility. Our group has prepared stimuli-responsive materials including hydrogels, peptides, and nanoparticles for drug delivery applications. These materials are responsive to a variety of triggers such as pH, reducing conditions, temperature, glucose, and enzymes that can be tuned based on their chemistry for various The basic mechanisms of stimuli‐responsive drug delivery systems can be described as follows: after injection, the stimuli‐responsive drug delivery system (nanocarriers) accumulates at a tumor site via passive (enhanced permeability and retention effect) or active (receptor–ligand affinity) targeting. Stimuli-responsive particles could find use in numerous applications in the chemical, coatings, cosmetic, detergent and food industries, as well as drug delivery and diagnostics where the stimuli Thermoresponsive and other stimuli-responsive polymers employed in drug delivery systems can be activated via ultrasound stimulation.

Köp Stimuli-responsive Drug Delivery Systems av Amit Singh, Mansoor M Amiji på Bokus.com. pH-responsive systems take advantage of the significant variations in pH to stimulate localized drug delivery to different regions of the body such as the gastrointestinal tract, tumor microenvironment, or to the endosomal/lysosomal compartments of the cell (Figure 1). Stimuli-responsive drug-delivery nanocarriers (DDNs) have been increasingly reported in the literature as an alternative for breast cancer therapy. Stimuli-responsive DDNs are developed with materials that present a drastic change in response to intrinsic/chemical stimuli (pH, redox and enzyme) and extrinsic/physical stimuli (ultrasound, Near-infrared (NIR) light, magnetic field and electric current). Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications, Volume One: Types and Triggers discusses, in detail, the recent trends in designing biodegradable and biocompatible single-responsive polymers and nanoparticles for safe drug delivery. Focusing on the most advanced materials and technologies, evaluation methods, and advanced synthesis techniques stimuli-responsive 2021-01-01 · Designing different stimuli-responsive drug delivery based on CD. At the end of the 20th century, heat-sensitive liposomes were used for local drug release to treat diseases, triggering the concept of stimuli-responsive drug delivery system ( Yatvin, Weinstein, Dennis, & Blumenthal, 1978 ). The basic mechanisms of stimuli‐responsive drug delivery systems can be described as follows: after injection, the stimuli‐responsive drug delivery system (nanocarriers) accumulates at a tumor site via passive (enhanced permeability and retention effect) or active (receptor–ligand affinity) targeting.
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förhöjda glukoskoncentrationer i  However, the MOF families and members, and the drug release mechanisms in MOF-based stimuli-responsive drug delivery systems (DDSs) are rarely summarized.

The nanoprobes used were found to offer dual pH and temperature responsive drug delivery capability, and are specifically targeted to cancer cells which also shows intracellular MR based diagnostic and tracking ability. 2021-04-07 STIMULI-RESPONSIVE DRUG DELIVERY SYSTEMS BASED ON MESOPOROUS SILICA NANOPARTICLES WONG MUN FEI EDDY School of Physical and Mathematical Sciences A thesis submitted to the Nanyang Technological University in partial fulfilment of the requirement for the degree of Master of Science The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible.
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Stimuli-sensitive polymersomes have emerged as novel programmable delivery systems in which the release of the encapsulated contents can be readily modulated by the stimulus. The stimuli-responsive release may result in significantly enhanced therapeutic efficacy and minimized possible side effects.

Stimuli-responsive drug delivery system prevents transplant rejection 13 August 2014 In a depiction of a hand transplant, researchers illustrate how injecting a hydrogel-drug combo beneath the skin molecular polymers and supramolecular pseudorotaxanes for stimuli-responsive drug delivery, which not only endow the delivery systems with flexible and robust attributes of non-covalent interactions but also meet the urgent need of human healthcare.18–20 Drug-delivery systems immobilized with supramolecular nanovalves, emerging as a Stimuli responsive drug delivery systems have emerged as one of the most innovative classes of polymer materials of modern materials science. The polymer architectures exhibiting a large change in their physico chemical behaviors in response to minor signals from the environments have fabricated pot Stimuli‑responsive drug delivery systems based on mesoporous silica nanoparticles Wong, Eddy Mun Fei 2018 Wong, E. M. F. (2018). Stimuli‑responsive drug Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery Authors Mahdi Karimi, Parham Sahandi Zangabad, Amir Ghasemi and Michael R Hamblin Published delivery systems activated by external remote triggers are also discussed. We conclude by discus-sing advantages and limitations of current strategies, as well as future opportunities and challenges in this area. KEYWORDS diabetes, drug delivery, insulin, stimuli-responsive 1 | INTRODUCTION c) Thermoresponsive drug delivery system: The use of temperature as a signal has been justified by the fact that the body temperature often deviates from the physiological temperature (37°C) in the presence of pathogens or pyrogens. This deviation is a useful stimulus that activates the release of therapeutic agents from various temperature-responsive drug delivery systems for diseases Therefore, various stimuli-responsive PMs have been developed for “smartly” controlling drug release as well as drug efficacy.